Binary regression analysis showed that compared with control subjects, T2D patients had a decreased level of circulating IgG against peptide antigens derived from IL6 (adjusted r2=0.034, p=0.0001), IL8 (adjusted r2=0.021, p=0.002) and TNF-α (adjusted r2=0.017, p=0.003). The gene discussed is TNF; the disease is type 2 diabetes mellitus.