Although WCE induced cell apoptosis in AR-positive LNCaP and 22Rv1 cells more significantly than in AR-negative PC-3 and DU145 cells, unexpectedly, the results showed that WCE also significantly inhibited the tumor growth without affecting the body weight in both the mouse models (Fig. 2a–c and Supporting Information Fig. S1a–c). This evidence concerns the gene AR and neoplasm.