CDH1 and neoplasm: Additionally, luteolin treatment can induce E-cadherin expression, decrease in vitro invasion activity, and suppress lung metastasis in s.c. PC-3 tumor model at 5 mg/kg thrice a week through intraperitoneal injection; oral administration of apigenin with 50 μg/mouse/day increases E-cadherin, inhibit nuclear translocation of β-catenin, and prolong survival of PCa transgenic mice TRAMP35,36.