The increase of FoxP3 expression in CD4+ T cell was further elevated in WD fed mice that developed more severe hypercholesterolemia due to low-density lipoprotein receptor (LDLr) deficiency (Ldlr−/−) (Fig. 2C, Supplemental Fig. 3B), which is in line with previous reports4. Here, CD4 is linked to familial hypercholesterolemia.