Proliferation assays revealed that CD4+ CD25− T cells derived from WD fed mice were less responsive towards suppression with CD4+ CD25+ Treg cells from SCD fed animals (Supplemental Fig. 6A) and CD4+ CD25− T cell proliferation was promoted in the presence of irradiated APCs obtained from WD fed mice compared to those from SCD fed mice (Supplemental Fig. 6B). This evidence concerns the gene CD4 and Schnyder corneal dystrophy.