PIK3CA and breast cancer: Besides, many important pathways that related to cancer especially BC are listed in the table, e.g., “hsa04151: PI3K-Akt signaling pathway” (p-value = 2.8 × 10−9), “hsa05200: Pathways in cancer” (p-value = 1.0 × 10−4), “hsa04014: Ras signaling pathway” (p-value = 4.1 × 10−4), “hsa04350: TGF-beta signaling pathway” (p-value = 1.4 × 10−3), “hsa04010: MAPK signaling pathway” (p-value = 1.2 × 10−3), “GO:0007219~Notch signaling pathway” (p-value = 1.3 × 10−2) and “hsa04115: p53 signaling pathway” (p-value = 6.8 × 10−8).