Interestingly, however, we found clear divergent results when we broke down the most prominent NUDIX cluster found by FUSION (NUDT4, NUDT5, NUDT6, NUDT7, NUDT8, and NUDT9) by depleting NUDT5 and NUDT9 in A549 and MCF7 cells (Fig. 8), overall indicating that, despite forming a clearly clustered network, the different cancer backgrounds may rely differently on the NUDIX hydrolases. The gene discussed is NUDT7; the disease is cancer.