SERPINA3 was found to be strongly up-regulated in all prion diseases: sCJD (FC = 40.3), vCJD (FC = 38.8), FFI (FC = 52.7), gCJD (FC = 39.1) and GSS (FC = 12.17, not significant) cases (Table 1). Here, GSS is linked to variant Creutzfeldt-Jakob disease.