SERPINA3 has been linked to neurodegeneration and in particular to AD pathology, since protein deposits have been found in association with Aβ-peptides in both non-congophilic amorphous and classical (pre)amyloid plaques42–45 but also in astrocytes, in few neurons and in neurofibrillary tangles46. The gene discussed is SERPINA3; the disease is Alzheimer disease.