SERPINA3 and variant Creutzfeldt-Jakob disease: As for SERPINA3, GFAP was up-regulated in all prion diseases, with the highest value observed in gCJD patients (FC = 5.2) and iCJD (FC = 5), sCJD (FC = 3), GSS (FC = 2.9, not significant) vCJD (FC = 2.8) and FFI (FC = 2.2).