We first performed intracellular cytokine staining of ex vivo peripheral blood mononuclear cells (PBMCs) from 38 patients with axial spondyloarthritis fulfilling the assessment of spondyloarthritis (ASAS) criteria28, 14 patients with rheumatoid arthritis (RA) matched for CRP, and 17 sex and age matched healthy donors (Supplementary Table 1 shows patient characteristics, Supplementary Fig. 1A shows flow cytometry gating strategy). Here, CRP is linked to spondyloarthropathy.