To further investigate the potential effects of this SNP on NFE2L2 expression, we integrated the SNP data from International Cancer Genome Consortium (ICGC) whole-genome sequencing and TCGA RNA-seq data to compare the mRNA expression level of NFE2L2 between cancer samples with and without this SNP and found that the presence of this SNP was associated with a significantly lower NFE2L2 expression across cancer types (paired Wilcoxon signed rank test, P = 4.9 × 10−4, Fig. 5d). The gene discussed is NFE2L2; the disease is cancer.