We initially examined available cell lines established from oral cancers and noted that Fbxo4 expression is reduced in all three oral cancer cell lines UM-SCC-74A (74 A), UM-SCC-74B (74B) and SCC9 cells compared to normal human oral karotinocyte (OHKC); more importantly, reduced Fbxo4 correlated with increased Fxr1 levels (Fig. 3c, d). This evidence concerns the gene FBXO4 and lip and oral cavity carcinoma.