MAPT and Alzheimer disease: Probable AD (seven patients) was diagnosed from the prolonged clinical picture dominated by progressive memory impairment and posterior parietal symptoms, absence of other neurological signs, together with MRI (focal hippocampal/posterior parietal atrophy) and CSF markers indicating abnormalities of abeta and tau proteins.14 One patient had a frontotemporal dementia with evidence of anterior horn cell disease.