Survival from staphylococcal pneumonia was not impaired in mice lacking TLR2 and bacterial clearance from the lungs was minimally impaired in the absence of TLR2 only after low‐dose infection; indeed, elimination of S. aureus from the lungs was slightly accelerated in TLR2−/− mice challenged with higher inocula of bacteria. Here, TLR2 is linked to infection.