The suggested effect of obesogenic diets on triglyceride storage (i.e., decreased triglyceride storage via CG4500 decreased expression) is at odds with current direct experimental evidence concerning triglyceride storage in response to HSD and HFD, which could be more evidence of aberrant signaling during an obesity-like state in the fly. The gene discussed is CHST3; the disease is obesity due to melanocortin 4 receptor deficiency.