NOTCH3 and cancer: The most prominent proteins of the “cell adhesion” group were integrins (ITG; Fig. 2C) and receptors with pivotal signaling functions in cancer biology, including ephrin receptors (EPH), EGFR, NOTCH3, the adhesion molecule L1CAM, receptor-type tyrosine-protein phosphatases (PTPR) as well as semaphorin receptors of the neuropilin (NRP) and plexin (PLXN) families (marked by dots in Fig. 2C).