Although the accumulation of intra-tumoral CD8+ T cells in ovarian carcinoma patients is strongly associated with increased levels of IFNγ and a longer survival (17, –19), the T-regulatory cell (Treg) subpopulation of tumor-associated CD4+ T cells is instrumental in immunosuppression (20, 21) and linked to an adverse clinical course (16, 22). The gene discussed is CD8A; the disease is neoplasm.