We report a novel inframe GIT2-BRAF fusion with breakpoints at intron 14 of GIT2 (band q24.11) and intron 8 of BRAF (band q34), with retention of exon 9 and higher in BRAF. There were no significant copy number changes observed, and no single copy gain at 7q34, therefore this fusion is the result of a deletion, and not tandem duplication; the same mechanism of MAPK activation has been described in pilocytic astrocytomas with FAM131B-BRAF fusions. The gene discussed is BRAF; the disease is pilocytic astrocytoma.