Currently, approaches to the clinical assessment of RA disease activity, such as the disease activity score in 28 joints (DAS28) require complicated algorithms with multiple parameters, including the number of swollen and tender joints, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, and visual analogue scale (VAS) score, etc. Moreover, the 28-joint ultrasound (US28) score and the simplified disease activity index (SDAI) and clinical disease activity index (CDAI) considers 28 joints, which is simple but could be time-consuming. This evidence concerns the gene CRP and rheumatoid arthritis.