Mutations in RYR1 have been associated with centronuclear myopathies [73] and CFTD [74], and also linked to a susceptibility to malignant hyperthermia (MH) [75], a rare but major complication of anesthesia that manifests itself through a lethal rise in body temperature and tetanic muscle contractions. Here, RYR1 is linked to autosomal dominant centronuclear myopathy.