We identified five poly-miRTS in Ara-C-metabolic genes (NT5C2 rs10786736 and rs8139, SLC29A1 rs3734703, DCTD rs7278, and RRM1 rs1042919) to be significantly associated with complete remission after AraC-based chemotherapy and/or OS and RFS in these Chinese AML patients. This evidence concerns the gene NT5C2 and acute myeloid leukemia.