The PRS for PD risk was nominally associated with t-tau in the expected direction (p = 0.02, OR = 0.36; higher PRS, lower CSF tau) but not with α-syn (p = 0.20, OR = 0.57), Aβ1–42 (p = 0.05, OR = 0.52; higher PRS, lower CSF Aβ1–42) or p-tau (p = 0.11, OR = 0.39) levels, although all of the ORs were also in the expected direction (Table 3). This evidence concerns the gene MAPT and Parkinson disease.