Furthermore, sGPVI has been shown to have advantages over P-selectin in terms of selectivity, specificity and age-dependence.[10,22] We have previously demonstrated that patients with RA have a decreased response to collagen induced platelet aggregation as well as increased levels of sGPVI, which supports the hypothesis that enhanced activation of the GPVI pathway occurs in patients with RA. This evidence concerns the gene GP6 and rheumatoid arthritis.