A total of nine chr3p25 and chr11p11 genes were functionally connected to genes in the KEGG bladder cancer pathway (E2F1, E2F3, EGFR, RAF1, RB1) or to other cancer-related genes (AKT2, PIK3CA, RB1, TRIO). The gene discussed is PIK3CA; the disease is urinary bladder carcinoma.