TGFB1 and Hepatic fibrosis: Consistent with this observation, TGF-β1 and procollagen-1 (COL1A1) were significantly induced by MCD diet (Fig 2C and 2D, upper panels) and positively correlated with the presence of CK19+ve cells (Fig 2C and 2D, lower panels), again supporting the association between DR and liver fibrosis.