AKT1 and eosinophilia-myalgia syndrome: This suggests that the VEGF binding to VEGFR-2 in vascular endothelial cells after endometrium anarrhea into the abdominal cavity might have activated the downstream PI3K/Akt/mTOR signaling pathway, therefore, increasing vascular permeability, enhancing the invasion ability of the ectopic endometrial cells and angiogenesis, promoting cell proliferation and reducing cell apoptosis to eventually cause EMs.