This suggests that the VEGF binding to VEGFR-2 in vascular endothelial cells after endometrium anarrhea into the abdominal cavity might have activated the downstream PI3K/Akt/mTOR signaling pathway, therefore, increasing vascular permeability, enhancing the invasion ability of the ectopic endometrial cells and angiogenesis, promoting cell proliferation and reducing cell apoptosis to eventually cause EMs. This evidence concerns the gene VEGFA and eosinophilia-myalgia syndrome.