RET and medullary thyroid gland carcinoma: Vandetanib, a reversible ATP-competitive multitarget tyrosine kinase inhibitor that targets RET, vascular endothelial growth factor receptor (VEGFR), and EGFR tyrosine kinases, is clinically available for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable, locally advanced, or metastatic disease.