EGFR and non-small cell lung carcinoma: Furthermore, in a recent phase Ib/II trial, osimertinib was used as a first-line treatment for advanced NSCLC harboring mutant EGFR, with a robust ORR (67%) and an extremely prolonged PFS of 22.1 months as compared with the first-generation EGFR TKI (8.4–13.1 months) [97].