However, our results indicate an increase of intracellular Aβ42 in the VC of aged mice which could be related to the increased expression of PS2, the main enzyme associated with Aβ42 production in AD [24, 25], and supported by previous studies that have shown that all the components of the gamma-secretase complex increase under stressful conditions, as in AD [26]. The gene discussed is PSEN2; the disease is Alzheimer disease.