Evidence for this comes from the work of Pichichero et al, (2010; 2011) showing that chrysin, a flavanoid found in acacia honey inhibited proliferation of melanoma cells via cell cycle arrest and apoptosis.77,79 Honey has also been shown to regulate expression of p53, the tumour suppressor protein and down regulate Bcl-2 an anti-apoptotic protein, found at high levels in numerous cancers.80 The anti-inflammatory effects of honey may also contribute to its anti-carcinogenic properties, particularly as inflammation has been shown to contribute to the progression of cancer.81 This evidence concerns the gene BCL2 and melanoma.