BRCA2 and breast cancer: Women carrying a BRCA1 mutation have a lifetime risk of 65–80% of developing breast cancer, while BRCA2 mutation carriers have a lifetime risk of 45–85%.10 BRCA1 and BRCA2 are tumor suppressor genes that encode large proteins of 1,863 and 3,418 amino acids, respectively.11 Previous research demonstrated that BRCA proteins are key regulators of important cellular processes such as DNA repair, transcription, as well as cell cycle and apoptosis in response to DNA damage.12