For example, in Ashkenazi Jews, virtually all the mutations in BRCA1 and BRCA2 genes are related to 185delAG, 5382insC, and 6174delT.22 Elucidation of founder mutations of BRCA1/2 genes can have a significant impact on the management of families with hereditary cancer at the level of the national healthcare system, ultimately making genetic testing more affordable and cost-effective. Here, BRCA1 is linked to hereditary cancer.