In conclusion, according to our experience, we suggest the use of seriated CRP, ESR, and PCT controls for patients undergoing total hip arthroplasty in the first 4 weeks after surgery; their evaluation during this period allows discriminating between early postoperative infection and reactive inflammatory phenomena and implementing, after an initial assessment of these indexes, appropriate investigations with diagnostic imaging if there is a suspect of late chronic and hematogenous infection. This evidence concerns the gene ESR1 and infection.