The OZR + TR group had a lower body fat content than the OZR group, as also shown by Disanzo and You who found that obesity led to an increase in endothelial growth factor A (VEGF-A) that is responsible for stimulating angiogenesis in adipose tissue counteracting glycolytic metabolism in this tissue and contributing to their decrease by exercise [31]. Here, VEGFA is linked to obesity due to melanocortin 4 receptor deficiency.