ANGPTL2 circulating levels cannot be associated with a specific disorder such as cancer, even not with a specific type of cancer: high ANGPTL2 concentrations were reported to be a potential marker of breast [32], esophageal [34], gastric [39, 42], and colorectal [38, 41] cancers (Table 2), but they are rather a marker of cellular dysfunction and associate with systemic inflammation, hypoxia, and oxidative stress common to the microenvironment of cancer cells [40]. The gene discussed is ANGPTL2; the disease is cancer.