Higher values are measured in patients with chronic or autoimmune diseases, and discrepancies between circulating levels reported in different studies are most likely due to the differences in age, ethnic background, geographical location, clinical characteristics, and/or severity of the disease and to a lesser extent to the ELISA kit used to quantify ANGPTL2 levels (Tables 1, 2, and 3). Here, ANGPTL2 is linked to autoimmune disease.