In addition, ANGPTL2 plays an active role in kidney disease: indeed, we observed that 3 months after renal transplantation, ANGPTL2 circulating levels were associated with aortic stiffness, central pulse pressure, and renal dysfunction, and the risk of mortality was significantly higher (3.9-fold) in patients with the highest posttransplant ANGPTL2 circulating levels [48]. This evidence concerns the gene ANGPTL2 and kidney disorder.