In conclusion, the clinical prognostic value of abnormal ANGPTL2 circulating levels should be confirmed and ANGPTL2 could then be included in the routine blood biochemical marker panel in association with the inflammatory marker hsCRP, the cardiac marker NT-proBNP or tumour markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen19-9 (CA19-9). The gene discussed is ANGPTL2; the disease is neoplasm.