Accordingly, it has been proposed that ANGPTL2 does not exert systemic effects on distant organs and that it rather acts locally: in a transgenic mouse model of ANGPTL2 overexpression in the skin (K14-ANGPTL2-Tg mice), renal fibrosis was not observed after unilateral uretal obstruction despite higher systemic ANGPTL2 levels [49], suggesting that it is the kidney-derived ANGPTL2 that causes renal fibrosis, not a global increase in systemic ANGPTL2 levels. This evidence concerns the gene ANGPTL2 and renal fibrosis.