ANGPTL2 and obesity due to melanocortin 4 receptor deficiency: Furthermore, increased levels of ANGPTL2 were reported in diabetes [5, 44–47], chronic kidney disease [9, 46, 48, 49], cardiovascular diseases [5, 7, 8, 26, 50–57], metabolic disorders including obesity [5, 55, 58–60], and other diseases (for review, [6]), including autoimmune diseases such as dermatomyositis [61] and rheumatoid arthritis [62] (Tables 1 and 3).