ANGPTL2 and diabetes mellitus: On the other hand, we recently reported that in severely obese patients, the relatively low reduction of ANGPTL2 levels after bariatric surgery (0% at 6 months, 18% at 1 year) does not reflect the drastic weight reduction (27% at 6 months, 37% at 1 year), but rather improvement in diabetes, dyslipidemia, and inflammation [60].