ANGPTL2 and dilated cardiomyopathy: Recently, it has been demonstrated that the heart can produce and secrete ANGPTL2: in patients with dilated cardiomyopathy, a difference between blood ANGPTL2 concentration measured in the coronary sinus and that measured in the aortic root reflected ANGPTL2 secretion directly from the heart, including from cardiomyocytes [68].