In this retrospective study, PITX2 DNA methylation was the only significant factor as assessed by univariate and multivariate survival analysis; in combination with PITX2 DNA methylation status; none of the established clinical and histomorphological parameters (age, histological grade, tumor size, and lymph node status) showed statistical significance for predicting the rate of disease-free or overall survival [66]. The gene discussed is PITX2; the disease is neoplasm.