ERBB2 and breast carcinoma: Currently, tyrosine kinase inhibitors (e.g., lapatinib and gefitinib) are applied in breast cancer patients to block EGF-stimulated growth signal transduction and that of HER2 and the combination of these drugs with carboplatin or docetaxel synergistically may enhance the treatment effect in TNBC patients [29, 34, 36–38].