Germacrone and curdione are also involved in 132 other signaling pathways including purine metabolism, calcium, CGMP-PKG, neuroactive ligand-receptor interaction, cytokine-cytokine receptor interaction, etc. signaling pathways that could explain their broad effects on cancer, inflammation, cardiovascular disease, hypertension, and neurodegenerative diseases (Supplementary Tables 2, 3)16. This evidence concerns the gene PRKG1 and hypertensive disorder.