PRKG1 and neurodegenerative disease: Germacrone and curdione are also involved in 132 other signaling pathways including purine metabolism, calcium, CGMP-PKG, neuroactive ligand-receptor interaction, cytokine-cytokine receptor interaction, etc. signaling pathways that could explain their broad effects on cancer, inflammation, cardiovascular disease, hypertension, and neurodegenerative diseases (Supplementary Tables 2, 3)16.