Based on the well investigated role of insulin as a brain satiety signal39 interfering with dopaminergic neurotransmission40,41 and the discovery of exaggerated beta oscillatory activity in the dopamine depleted basal ganglia system of parkinsonian patients20, it is tempting to formulate the hypothesis that beta oscillatory activity and coherence in obesity might constitute a relevant modality of reward regulation through central insulin signaling. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.