A univariate analysis revealed that cirrhosis (P = 0.026), serum AFP levels (P = 0.003), number of hepatic tumors (P < 0.001), and ADAM21 positivity (P < 0.001) (Fig. 4C) were prognostic factors for recurrence-free survival (RFS) (Table 3). This evidence concerns the gene ADAM21 and Cirrhosis.