We also identified five non-HLA variants in retinoic acid early transcript 1E (RAET1E), NLR protein 11 (NLRP11), and HCAR2. NM_139165:exon5:c.623-2->TT was located in RAET1E. The variants identified were significantly enriched in HCC patients, and rare or no variants were found enriched in controls. This evidence concerns the gene HCAR2 and hepatocellular carcinoma.