CTNNB1 and thalassemia: Figure 4B exemplarily shows the effect of common SVs on the cardiac transcription; for example, an upregulation of the gene expression was found in the chromatin remodeler gene Alpha Thalassemia/Mental Retardation Syndrome X‐Linked (ATRX), Keratin 1 (KRT1), involved in activation of the immune system and beta catenin signaling, and Serpin family C member 1 (SERPINC1), involved in blood coagulation.