We also tested DLD1 cells (colorectal adenocarcinoma cell line, 46 chromosomes occurring in 86% of population) for the effects of HAS1 overexpression using a tetracycline-inducible system and observed similar outcome of emergent population’s diversity (shown as nuclear perimeter) when HAS1 was overexpressed (4 weeks induction with 3 μg/ml of Dox), but no effects on nuclear morphology in control cells (pTET) or cells that overexpressed the related HAS2 (Fig. 3c). Here, HAS1 is linked to colorectal adenocarcinoma.