Among the histotypes of endometrial carcinoma, p53 aberrations represent the most frequently identified recurring molecular event in serous carcinomas [9, 10] and carcinosarcomas [11, 12] but have also been identified in significant subsets of high grade endometrioid [13], clear cell [14] and dedifferentiated/undifferentiated carcinomas [15, 16]. Here, TP53 is linked to endometrial carcinoma.