In this report, the authors describe one such case - a low grade endometrioid carcinoma of the endometrium showing a p53-aberrant immunophenotype in one portion of the tumor, MSH2 and MSH6 loss in all components, and a distinctive pattern of lymph node metastases in multiple lymph nodes comprised of both the p53 wild-type and p53-aberrant components. Here, TP53 is linked to endometrioid adenocarcinoma.