The meta-analysis suggested that blood TNF-α (8 studies, Hedges’ g = 1.045, 95% CI = 0.077 to 2.013, p = 0.034), IL-1β (5 studies, Hedges’ g = 0.683, 95% CI = 0.027 to 1.34, p = 0.041), IFN-γ (6 studies, Hedges’ g = 0.978, 95% CI = 0.306 to 1.651, p = 0.004) and neopterin (4 studies, Hedges’ g = 0.722, 95% CI = 0.271 to 1.173, p = 0.002) levels were significantly increased in DS patients compare with controls. This evidence concerns the gene TNF and Dravet syndrome.