Random effects meta-analysis demonstrated that patients with DS had significantly higher circulating inflammatory marker levels compared with HC subjects for TNF-α (Hedges’ g = 1.045, 95% confidence interval (CI) = 0.192 to 1.898, p = 0.016), IL-1β (Hedges’ g = 0.696, 95% CI = 0.149 to 1.242, p = 0.013), IFN-γ (Hedges’ g = 0.978, 95% CI = 0.417 to 1.539, p = 0.001) and neopterin (Hedges’ g = 0.815, 95% CI = 0.423 to 1.207, p < 0.001), as shown in Table 2 and Figure 2. The gene discussed is IL1B; the disease is Dravet syndrome.