PITX1 [10–15], CST6 [16, 17] and HOPX [18–21] were reported their downregulation in various types of human cancer, and PRSS27 [22] was known to be highly expressed in nonkeratinizing stratified squamous epithelia of human esophagus and its dysregulation was supposed to be related to characteristics of carcinoma. Here, PRSS27 is linked to carcinoma.