Importantly, one of the largest studies on PTEN loss and PCa recurrence to date by Lotan and coworkers [12], showed that PTEN loss was more strongly associated with recurrence-free survival among patients that harbored the gene fusion; but the authors also noted that there was no statistically significant interaction between PTEN loss and TMPRSS2:ERG fusion status. Here, PTEN is linked to posterior cortical atrophy.