Although no research has demonstrated an association between ATP1B3 and gastric cancer, the well-known Na+/K+-ATPase inhibitors, including digoxin, ouabain, arenobufagin and bufalin, induced cell cycle arrest and apoptosis in many human cancer cells, including those derived from NSCLC [25], hepatoma [26] and pancreatic cancer [27]. This evidence concerns the gene ATP1B3 and gastric cancer.