When compared with conventional administration, NGR-PEG-LP-ZOL and PEG-LP-ZOL metronomic administration showed no significant reduction in the expression of CD206 specific protein in tumor tissues as well as the mRNA expression of TAMs phenotypic molecules (Arg1, Fizz, Msr2, CCL3, CCL22), but reduced the percentage of TAMs. The gene discussed is CCL22; the disease is neoplasm.