The possible reasons for aberrant caspase-3 expression may be that low expression of caspase-3 render cancer cells resistant to microenvironmental stresses [26, 27], and the overexpression of caspase-3 in dying cells may release growth-stimulating signals to allow non-apoptotic tumor cells to proliferate and survive under stressful conditions [22, 28]. Here, CASP3 is linked to cancer.