CASP3 and metastatic malignant neoplasm in the lymph nodes: In conclusion, cleaved caspase-3 and caspase-3 could be biomarkers for tumorigenesis and prognosis, in particular, the high expression of caspase-3 is associated with the prognosis of BMSCC patients who receive postoperative RT, and the positive/high expression of either or both cleaved caspase-3 and caspase-3 is associated with prognosis of BMSCC patients with early pathological stage or without lymph node metastasis.