However, elevated caspase-3 expression has been observed in tumor tissues of several cancer types, including glioblastoma [15], melanoma [16], acute myelogenous leukemia [24], breast carcinoma [17, 25], pancreatic ductal carcinoma [18], non-small cell lung cancer [19] and OSCC [21]. This evidence concerns the gene CASP3 and acute myeloid leukemia.