CASP3 and cancer: In contrast to our results, the high expression of caspase-3 was found to be associated with poor cell differentiation and lymph node invasion in OSCC [21], likely due to the fact that the association of caspase-3 expression with pathological outcomes in oral cancer is dependent on the site of cancer [33], as well as different environmental exposures and genetic alterations between Asian and Western BMSCC patients.