Furthermore, several lncRNAs, such as metastasis-associated lung adenocarcinoma transcription 1 (MALAT1), HOTTIP, and HOTAIR, have been characterized as negative prognostic factors in PC patients, indicating that they might exert pro-oncogenic roles in vitro and in vivo [10, 16, 19, 26, 31]. The gene discussed is HOTTIP; the disease is pachyonychia congenita.