TNS4 and metastatic malignant neoplasm in the lymph nodes: The protein expression of CTEN was significantly associated with more aggressive venous (P = 0.0018) and lymphatic invasion (P = 0.0155), deeper depth of invasion (P < 0.0001), and higher rates of lymph node metastasis (P = 0.0006) and recurrence (P = 0.0008), whereas other characteristics including the Siewert classification and histological grade were not.