TNS4 and metastatic malignant neoplasm in the lymph nodes: Regarding previous studies on CTEN, Sakashita et al. showed that TNS4 (CTEN) was frequently overexpressed in primary gastric cancer tissues, and gastric cancer patients with high TNS4 (CTEN) mRNA expression significantly had a poor prognosis associated with lymph node metastasis and peritoneal dissemination.