Although it showed tumor-suppressor functions in prostate cancer [13], in primary tumors, CTEN was significantly overexpressed in many types of primary cancers including thymoma, gastric, colorectal, breast, lung, skin, and pancreatic cancer [14, 15, 18–20, 25–32] and was a clinically relevant prognostic marker for these cancers. Here, TNS4 is linked to neoplasm.