SNHG12 and non-small cell lung carcinoma: Moreover, SNHG12 knockdown reversed the MDR of NSCLC cells, evidenced by a significant decrease in the IC50 of cisplatin, paclitaxel and gefitinib in si-SNHG12-transfected resistant cell strains compared with that of si-Con-transfected cells (Figure 3D-3F).