Methylation of FOXC1 was significantly higher in APL samples compared to non-APL AML (mean methylation 11% in 23 APL, vs 6% in 24 AML p = 0.010, Figure 2A), and decreased after consolidation treatment in all APL tested (16 APL, mean 5%, p = 0.0001, Figure 2A). This evidence concerns the gene FOXC1 and acute promyelocytic leukemia.