At 24 hours after sepsis diagnosed, the plasma RIPK3 and RIPK1 levels were 7.9 (3.2–16.7) pg/mL and 7.1 (2.7–15.6) pg/mL for sepsis patients, 11.3 (1.2–19.2) pg/mL and 8.4 (1.8–14.5) pg/mL for severe sepsis patients, as well as 18.9 (3.6–32.5) pg/mL and 8.9 (2.4–25.1) pg/mL for septic shock patients. The gene discussed is RIPK1; the disease is septic shock.