Our data showed that TFPI2 methylation in tumor tissues was significantly higher than that in paired adjacent tissues [GC: 29.940% (15.472%, 47.295%) versus 12.785% (9.678%, 16.575%), P < 0.001; CRC: 26.930% (8.478%, 63.145%) versus 5.420% (1.345%, 16.638%), P < 0.00001; Figure 2A]. This evidence concerns the gene TFPI2 and neoplasm.