Recently, many epigenetic biomarkers have been studied in cancer diagnosis, including hMLH1, E-cadherin, CDKN2A, CDKN2B and APC [33] in GC and SEPT9, SFRP2, THBD, SDC2, VIM and FBN1 in CRC [34]. The gene discussed is CDKN2B; the disease is colorectal carcinoma.