AKT1 and neuroblastoma: Many of those pathways were previously published in relation with the severity of neuroblastoma, such as AKT signaling [31], cAMP- and IP3–dependent signal transduction mechanisms [32, 33], and also estrogen [34], growth hormone signaling regulating glucose uptake [35], MAPK [36], PPAR [37], NGF [38] and Ras [36] signaling.